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Miguel Martínez-Calvo, Sandra A. Bright, Emma B. Veale, Adam F. Henwood, D. Clive Williams, Thorfinnur Gunnlaugsson
《化学科学与工程前沿(英文)》 2020年 第14卷 第1期 页码 61-75 doi: 10.1007/s11705-019-1862-8
关键词: sensors pH photoinduced electron transfer cellular imaging confocal microscopy
用于细胞成像的共聚焦内窥镜 Article
王家福,杨敏,杨莉,张云,袁菁,刘谦,侯晓华,付玲
《工程(英文)》 2015年 第1卷 第3期 页码 351-360 doi: 10.15302/J-ENG-2015081
使用内窥镜的目的是实现与组织病理诊断相符的即时诊断。在过去的十年里,共聚焦激光扫描显微成像技术被引入内窥镜领域。共聚焦内窥镜使得对活体组织的显微观察能够达到与组织学样品的体外显微成像相当的放大倍数和分辨率。发展这种内窥镜的主要挑战在于具有微米级分辨率的显微成像光纤探头的小型化。笔者研制了一套基于光纤束,分辨率为1.4 μm, 成像速度可达8 fps的共聚焦内窥镜系统。光纤探头的直径为2.6 mm,可与常规内窥镜的活检通道兼容。该共聚焦内窥镜的样机已经被用于观察小鼠胃肠道上皮细胞,并将进一步被用于临床试验。此外,该共聚焦内窥镜能够被用于上皮细胞功能的转化研究,以监测自然生理环境中细微颗粒的功能和细胞间的相互作用。
Regulation of T cell immunity by cellular metabolism
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 463-472 doi: 10.1007/s11684-018-0668-2
T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.
关键词: T cell immunity metabolic pathways nutrient uptake metabolic checkpoints
Parametric sensitivity analysis of cellular diaphragm wall
Xi CHEN, Wei XU
《结构与土木工程前沿(英文)》 2012年 第6卷 第4期 页码 358-364 doi: 10.1007/s11709-012-0177-3
关键词: cellular diaphragm wall sensitivity analysis optimization centrifuge model test
Liver cell therapies: cellular sources and grafting strategies
《医学前沿(英文)》 2023年 第17卷 第3期 页码 432-457 doi: 10.1007/s11684-023-1002-1
关键词: liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies
Optimization of Land-use Based on the Theory of Cellular Automata and Value of Ecosystem Services
Lian-fu Jiang,Guo-xian Xu,Hao Jiang
《工程管理前沿(英文)》 2014年 第1卷 第4期 页码 395-401 doi: 10.15302/J-FEM-2014058
关键词: Ecosystem service function optimization of land use Cellular Automata (CA)
evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2
null
《医学前沿(英文)》 2014年 第8卷 第4期 页码 471-476 doi: 10.1007/s11684-014-0365-8
This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidney injury in type 2 diabetic patients with normoalbuminuria (NAU) versus microalbuminuria (MAU) prospectively. A total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU group (n = 14) or MAU group (n= 16) according to 8 h overnight urinary albuminuria excretion rate (AER) results. A contemporary cohort of health check-up recipients were included as controls (n = 12). DWI and DTI scans were performed on bilateral kidney using SE single-shot EPI, and apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the renal parenchyma was determined from ADC and FA maps of the three groups. ADC and FA values were compared among the three groups. According to DWI with a b value of 400 s/mm2, the MAU and NAU groups showed significantly lowered mean ADC values compared with the healthy controls (P<0.01). The mean ADC in the MAU group [(2.22±0.07)×10–3 mm2/s] was slightly lower than that of the NAU group [(2.31±0.22)×10–3 mm2/s], but this difference was not statistically significant (P>0.05). The FA value in the MAU group was higher than that in the control group (0.45±0.07 vs. 0.39±0.03, P = 0.004) but did not differ from that in the NAU group (0.42±0.03) (P>0.05). ADC and FA values may be more sensitive than urine AER in reflecting early-stage kidney injury and, hence, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients. Combined evaluation of ADC and FA values may provide a better quantitative approach for identifying diabetic nephropathy at early disease stages.
关键词: type 2 diabetes mellitus microalbuminuria diffusion weighted imaging diffusion tensor imaging early-stage kidney injury
《结构与土木工程前沿(英文)》 2021年 第15卷 第3期 页码 781-792 doi: 10.1007/s11709-021-0733-9
关键词: lightweight cellular concrete construction-induced damage freeze-thaw action microstructure degradation mechanism
Macro-architectured cellular materials: Properties, characteristic modes, and prediction methods
Zheng-Dong MA
《机械工程前沿(英文)》 2018年 第13卷 第3期 页码 442-459 doi: 10.1007/s11465-018-0488-8
Macro-architectured cellular (MAC) material is defined as a class of engineered materials having configurable cells of relatively large (i.e., visible) size that can be architecturally designed to achieve various desired material properties. Two types of novel MAC materials, negative Poisson’s ratio material and biomimetic tendon reinforced material, were introduced in this study. To estimate the effective material properties for structural analyses and to optimally design such materials, a set of suitable homogenization methods was developed that provided an effective means for the multiscale modeling of MAC materials. First, a strain-based homogenization method was developed using an approach that separated the strain field into a homogenized strain field and a strain variation field in the local cellular domain superposed on the homogenized strain field. The principle of virtual displacements for the relationship between the strain variation field and the homogenized strain field was then used to condense the strain variation field onto the homogenized strain field. The new method was then extended to a stress-based homogenization process based on the principle of virtual forces and further applied to address the discrete systems represented by the beam or frame structures of the aforementioned MAC materials. The characteristic modes and the stress recovery process used to predict the stress distribution inside the cellular domain and thus determine the material strengths and failures at the local level are also discussed.
关键词: architectured material cellular materials multi-scale modeling homogenization method effective material properties computational method
A review of intelligent optimization for group scheduling problems in cellular manufacturing
《工程管理前沿(英文)》 页码 406-426 doi: 10.1007/s42524-022-0242-0
关键词: cellular manufacturing group scheduling flowshop literature review
Vaibhav Mundra, Ram I. Mahato
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 387-404 doi: 10.1007/s11705-014-1457-3
关键词: nanocarrier cellular uptake endosomal release nucleic acid drug
Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice
《化学科学与工程前沿(英文)》 2023年 第17卷 第3期 页码 298-306 doi: 10.1007/s11705-022-2212-9
In vivo imaging of hematopoietic stem cell development in the zebrafish
Panpan Zhang, Feng Liu
《医学前沿(英文)》 2011年 第5卷 第3期 页码 239-247 doi: 10.1007/s11684-011-0123-0
关键词:
hematopoietic stem cell
hematopoiesis
Jadav Chandra DAS,Debashis DE
《信息与电子工程前沿(英文)》 2016年 第17卷 第3期 页码 224-236 doi: 10.1631/FITEE.1500079
关键词: Quantum-dot cellular automata (QCA) Parity generator Parity checker Feynman gate Nanocommunication Power dissipation
Tangchun Wu
《医学前沿(英文)》 2020年 第14卷 第6期 页码 816-819 doi: 10.1007/s11684-020-0823-4
标题 作者 时间 类型 操作
Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomal cellularimaging agents: The effect of substituent patterns on PET directional quenching
Miguel Martínez-Calvo, Sandra A. Bright, Emma B. Veale, Adam F. Henwood, D. Clive Williams, Thorfinnur Gunnlaugsson
期刊论文
Optimization of Land-use Based on the Theory of Cellular Automata and Value of Ecosystem Services
Lian-fu Jiang,Guo-xian Xu,Hao Jiang
期刊论文
evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2
null
期刊论文
Influence of construction-induced damage on the degradation of freeze–thawed lightweight cellular concrete
期刊论文
Macro-architectured cellular materials: Properties, characteristic modes, and prediction methods
Zheng-Dong MA
期刊论文
Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic
Vaibhav Mundra, Ram I. Mahato
期刊论文
Quantum-dot cellular automata based reversible low power parity generator and parity checker design for
Jadav Chandra DAS,Debashis DE
期刊论文